Alprazolam is extensively metabolized in humans, primarily by cytochrome P450 3A4 (CYP3A4), to two major metabolites in the plasma: 4-hydroxyalprazolam ... The antidepressant efficacy of alprazolam (ALP) was tested in a double-blind controlled comparison with desipramine (DMI) and an ALP-DMI combination in ... [ More results from www.ncbi.nlm.nih.gov ]
The ability of alprazolamto induce human hepatic enzyme systems has not yet been determined. However, this is not a property of benzodiazepines in general.
Children with overanxious and/or avoidant disorder (DSM-III) were treated with alprazolam(Xanax, Upjohn) to determine its safety, clinical and cognitive effects.